Diagnosis of Hirschsprung's disease by punch biopsy of rectum.
نویسندگان
چکیده
234 punch biopsy specimens of rectal tissue were taken from 112 children. In 94% of the patients the diagnosis of Hirschsprung's disease was confirmed or refuted by the first biopsy. There were no false-positive or false-negative results. One patient developed a serious complication, a pelvic haematoma.
منابع مشابه
A clinical evaluation of anorectal pressure studies in the diagnosis of Hirschsprung's disease.
Stimulation of the rectum by stretch results, in the normally innervated bowel, in the reflex relaxation of the internal anal sphincter. The absence of this rectosphincteric reflex in Hirschsprung's disease forms the basis of a simple and safe diagnostic test. Our experience over two years using a simplified air-filled pressure probe system is described, based on the examination of 267 infants ...
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Hirschsprung's disease (HD) is a disorder that involves several medical specialties such as paediatric gastroenterology, paediatric surgery, and pathology. Hirschsprung's disease is a congenital bowel innervation disorder characterised by the absence of ganglion cells in myenteric (Auerbach) and submucosal (Meissner) plexus in the distal colon in its classical form. Rapid and accurate diagnosis...
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Background Rectal biopsy and its histopathological study with hematoxylin and eosin (HE) is the gold standard for Hirschsprung's disease (HD) diagnosis. However, there are some limitations in the diagnosis of ganglion cells in HE approach. Recently, it was reported that the utility of Calretinin is a reliable ancillary immunohistochemistry (IHC) test for HD diagn...
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عنوان ژورنال:
- Archives of disease in childhood
دوره 51 7 شماره
صفحات -
تاریخ انتشار 1976